Basics of Nuclear Magnetic Resonance (FUN)

It aims at providing students and professionals the basic knowledge about NMR. The MOOC sets out the principles of solution-state NMR as well as one- and two-dimensional 1H and 13C NMR experiments and their application on small organic molecules in solution.

At the end of the course, you will know how this technique can be employed to determine the structure of small organic molecules in solution (including stereochemical aspects), or to evaluate their purity.
This course is intended for undergraduate and graduate students as well as educators and professionals who need to gain proficiency as routine users of NMR spectroscopy of organic molecules in solution. This multi-disciplinary course will appeal to students and professionals with background in chemistry, physics, material sciences, pharmacology, medicine and Earth sciences.

Prerequisites
Students should have a background in basic chemistry, including: (i) the atoms, the elements and the periodic table; (ii) the structure of organic molecules (functional groups, stereochemistry); as well as in basic physics, including some knowledge about the spectroscopy (energy levels, photon, frequency) and the magnetism.

COURSE SYLLABUS

Week 1: Importance of NMR and the basic principles of NMR spectroscopy.
Week 2: NMR experiment and 1H NMR of organic molecules in solution.
Week 3: Probing covalent bonds and connectivities in organic molecules via J-couplings.
Week 4: 13C NMR of organic molecules in solution.
Week 5: 2D NMR of organic molecules in solution.